Blood flow in transplanted tumors: quantitative approaches to radioisotopic studies.
نویسنده
چکیده
Descriptions of the weight of a tumor and the magnitude of its blood flow have been of interest for a number of years. Despite this, there have been no reported attempts to provide quantitative relationships between the tumor's weight and its rate of perfusion. An initial approach to such a relationship, which adequately describes all known data in the literature thus far, is given in the present communication. In this inquiry, we are hampered by a lack of knowledge as to possible "cause and effect." However, we will arbitrarily describe blood flow as a function of tumor weight, and seek interrelations. Such an approach has only become possible in the last few years with the availability of radioisotopic techniques for estimating "functional" blood flow distribution.
منابع مشابه
Effect of vasoactive drugs on tissue blood flow in the hamster melanoma.
Previous quantitative estimates of blood flow of transplanted tumors have been lower than surrounding tissue. Using a modifi cation of the Fick principle with antipyrine-131!, tissue blood flow was estimated in the hamster amelanotic melanoma implanted in subcutaneous tissue over the femoral triangle. Mean tumor blood flow was higher than adjacent tissue, decreased with tumor age, and responded...
متن کاملRegional measurements of blood flow in experimental RG-2 rat gliomas.
Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ventricular, and two fourth-ventricular tumors were studied. For all tumors, ave...
متن کاملNewtonian and Non-Newtonian Blood Flow Simulation after Arterial Stenosis- Steady State and Pulsatile Approaches
Arterial stenosis, for example Atherosclerosis, is one of the most serious forms of arterial disease in the formation of which hemodynamic factors play a significant role. In the present study, a 3-D rigid carotid artery with axisymmetric stenosis with 75% reduction in cross-sectional area is considered. Laminar blood flow is assumed to have both Newtonian and non-Newtonian behavior (generalize...
متن کاملQuantitative assessment of salivary gland function by radioisotopic scanning in a randomized trial of Pilocarpine for prevention of radiation induced Xerostomia [Persian]
Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of...
متن کاملAbsence of host-site influence on angiogenesis, blood flow, and permeability in transplanted RG-2 gliomas.
The host site is believed to regulate tumor angiogenesis, which could result in site-dependent drug delivery parameters, greatly affecting experimental tumor research. In RG-2 rat gliomas we measured cellular proliferation; cell cycle time was the same for RG-2 cells in brain and s.c. tumors (25 h), and was the same for endothelial cells in these tumors (46 h). We measured the transcapillary tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 43 شماره
صفحات -
تاریخ انتشار 1970